Modeling of pathogenic breathing pattern dysregulation in cardiopulmonary disease

Reference: 5R33HL087347 Abstract: Ventilatory arrhythmia plays a pathogenic role in many common respiratory disorders ranging from sleep apnea, and acute lung injury to ventilatory support in the setting of chronic lung disease. Brainstem neural circuits that control cardiopulmonary functions generate oscillatory patterns that drive respiratory as well as sympathetic motor activities. These patterns exhibit highly … Read more

Epigenetics of chronic heart failure

Reference: Abstract: The focus of this project are epigenetic mechanisms that underlie the remodeling in the heart in the emergence of hypertrophy and failure and recovery after mechanical unloading.ᅠIn the foreground is the methyl-DNA-binding protein 2 (MeCP2), which specifically recognizes methylated DNA sequences, and thus can modulate gene expression.ᅠIn the continuation phase of this project, … Read more

Functional variants of the 5q31 chromosome region: connections between polygenic diseases and the carnitine system.

Reference: 73430 Abstract: The study design is the natural extension of our previous research works that had already been supported (www.humangenom.hu, www.eurosca.org). It is clear nowadays, that the functions of the carnitine are not restricted to the role of the oxidation of the long-chain fatty acids. The main direction of the planned research is the … Read more

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