2008.

Participatory research into quality of life of adults with intellectual disabilities

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Reference: 57000005 Abstract: This is a summary of the request. The Governor Kremers Centre (GKC) started in 2002 as a corporate initiative of service providers and the academic chair on intellectual disability at Maastricht University. It is now aiming at extending and consolidating its activities as a consortium of Maastricht University, major service providers and … Read more

ROLE OF EXCITATION AND INHIBITION IN RETT SYNDROME

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Reference: 1F31MH078678n.a.1A2 Abstract: MeCP2 is a transcriptional repressor critical for normal neurological function. Rett syndrome (RTT) is a progressive neurodevelopmental disease caused by predominantly loss of function mutations in the X-linked gene encoding the transcriptional repressor, methyl-CpG-binding protein 2 (MECP2) genes. Classic RTT patients exhibit a spectrum of neurological phenotypes that include tremors, ataxia, seizures, … Read more

Partnership research in biotechnology for health (BIOTECS) 2008 project�RETTcure – Modulators of bio-aminergic pathways for the treatment of Rett syndrome

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Reference: ANRn.a.8-BIOTn.a.020 Abstract: Rett syndrome (RS) is a severe neurological disorder caused by a mutation in the MECP2 gene transcriptional repressor.�SR girls develop normally until 6-18 months later, they suffer neurological symptoms and severe respiratory ?irregularities.�So far no treatment is available.�Previously, using a mouse model of SR, we have shown that disruption of the respiratory … Read more

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