United States – Page 4 – Rett syndrome research – projects, results and publications

ROLE OF EXCITATION AND INHIBITION IN RETT SYNDROME

June 16, 2021June 29, 2015 by Editorial Team

Reference: 1F31MH078678n.a.1A2 Abstract: MeCP2 is a transcriptional repressor critical for normal neurological function. Rett syndrome (RTT) is a progressive neurodevelopmental disease caused by predominantly loss of function mutations in the X-linked gene encoding the transcriptional repressor, methyl-CpG-binding protein 2 (MECP2) genes. Classic RTT patients exhibit a spectrum of neurological phenotypes that include tremors, ataxia, seizures, … Read more

Investigating the Molecular Basis of FSHD

June 16, 2021June 29, 2015 by Editorial Team

Reference: R01 NS047584n.a.1- Tupler, Rossella Abstract: n.a PROJECT DETAILS beginning: 2003. end: 2008. Country of research: Italy Counry of funding source: United States Funding organization: National Institutes of Health; US Financing: NATIONAL FUNDINGS – 853 913 € hyperlink

Modeling of pathogenic breathing pattern dysregulation in cardiopulmonary disease

June 16, 2021June 29, 2015 by Editorial Team

Reference: 5R33HL087347 Abstract: Ventilatory arrhythmia plays a pathogenic role in many common respiratory disorders ranging from sleep apnea, and acute lung injury to ventilatory support in the setting of chronic lung disease. Brainstem neural circuits that control cardiopulmonary functions generate oscillatory patterns that drive respiratory as well as sympathetic motor activities. These patterns exhibit highly … Read more

Neurobehavioral phenotyping of genetically modified mouse models of mental retardation

June 16, 2021June 29, 2015 by Editorial Team

Reference: ISS-NIH 5301/530H Abstract: PROJECT DETAILS beginning: n.a end: n.a Country of research: Italy, US Counry of funding source: United States Funding organization: Bilateral Italy (ISS)ﾗUSA (NIH, Office for rare diseases) Financing: NATIONAL FUNDINGS – 0 € hyperlink

ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS

June 16, 2021June 29, 2015 by Editorial Team

Reference: 1Z01MH002179-22 Abstract: Relevant to our research interests in animal models of neuropsychiatric diseases, our Laboratory of Behavioral Neuroscience investigates the behavioral phenotypes of transgenic and knockout mice with mutations in genes expressed in brain pathways involved in neuropsychiatric disorders. We developed and refined a multi-tiered strategy for mouse behavioral phenotyping that is widely used … Read more