United States

Investigation of the Importance of a hitherto Uncharacterized Mecp2-Isoform for Neuronal Morphogenesis and Chromatin related functions

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Reference: Charlotte Kilstrup-Nielsen Abstract: MeCP2 is a protein that has been found to bind and probably regulate important aspects of chromatin but it is still not clear how defects in MeCP2 cause the neurologic problems of RTT. It has become clear that MeCP2 gets phosphorylated in neurons that are activated by external stimuli but we … Read more

Molecular pathologies and functional interactions of the X-linked MECP2 and CDKL5 genes

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Reference: Charlotte Kilstrup-Nielsen Abstract: Rett syndrome (RTT) is a severe pediatric neurological disorder that, because of its incidence, represents the most common genetic cause of severe intellectual disability in girls worldwide. Several RTT variants have been described ranging from milder forms with a later age of onset to conditions with very early severe epileptic manifestations. … Read more

The MECP2 Consortium is a dynamic collaboration between the laboratories of three distinguished scientists, Adrian Bird, Michael Greenberg and Gail Mandel.

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Reference: MECP2 Consortium Abstract: n.a Made possible by a $1 million gift by RSRT Trustee Anthony Schoener and his wife Kathy, the Consortium was formed to definitively determine how this complex protein, MeCP2, functions and exerts its powerful influence on the human brain. Deep knowledge of its structure and roles in neurological development and maintenance … Read more

A research Consortium to define the function of MeCP2: A step towards the development of therapeutics for treating Rett Syndrome

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Reference: Adrian Bird Abstract: n.a PROJECT DETAILS  beginning: 2011. end: 2014. Country of research: United Kingdom Counry of funding source: United States Funding organization: Rett Syndrome Research Trust Financing: PRIVATE FUNDERS – 442 254 € hyperlink

Characterization of novel proteins influencing MeCP2 activity and analysis of their possible involvement in Rett Syndrome

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Reference: Charlotte Kilstrup-Nielsen Abstract: n.a PROJECT DETAILS  beginning: 2004. end: 2006. Country of research: Italy Counry of funding source: United States Funding organization: Research Sponsor: Robert C. & Adele R. Schiff Foundation Financing: PRIVATE FUNDERS – 59 120 € hyperlink

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