n.a – Page 11 – Rett syndrome research – projects, results and publications

MeCP2 interaction with DNA and its role on chromatin organization and subsequent changes of gene expression profile in Rett syndrome

June 16, 2021June 29, 2015 by Editorial Team

Reference: ORPHA229402 Abstract: 1 PROJECT DETAILS beginning: n.a end: n.a Country of research: Germany Counry of funding source: EU Funding organization: E-RARE Financing: EU-CORDIS – 0 € hyperlink

NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines

June 16, 2021June 29, 2015 by Editorial Team

Reference: Abstract: eurotrophins, particularly, NGF and BDNF are now well recognized to mediate a dizzying number of trophobiological effects, ranging from the Rita Levi-Montalciniﾒs neurotrophic through immunotrophic to metabotrophic effects. These are implicated in the pathogenesis of various diseases including neuropsychiatric and cardiometabolic diseases, such as dementia, depression, type 2 diabetes and obesity that may … Read more

DNA methylation 40 years later: its role in human health and disease

June 16, 2021June 29, 2015 by Editorial Team

Reference: Abstract: A long path, initiated more than 40 years ago, has led to a deeper understanding of the complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the imbalance in the epigenetic control of gene expression may profoundly alter the finely tuned machinery leading to gene regulation. Here, we review the … Read more

Partial rescue of Rett syndrome by omega-3 polyunsaturated fatty acids (PUFAs) oil

June 16, 2021June 29, 2015 by Editorial Team

Reference: Abstract: Evidence of enhanced oxidative stress (O.S.) and lipid peroxidation has been reported in patients with Rett syndrome (RTT), a relatively rare neurodevelopmental disorder progressing in 4-stages, and mainly caused by loss-of-function mutations in the methyl-CpG-binding protein 2. No effective therapy for preventing or arresting the neurologic regression in the disease in its various … Read more

Lessons from two human chromatin diseases, ICF syndrome and Rett syndrome

June 16, 2021June 29, 2015 by Editorial Team

Reference: Abstract: Spatial Organisation of DNA into chromatin profoundly affects gene expression and function. The recent association of genes controlling chromatin structure to human pathologies resulted in a better comprehension of the interplay between regulation and function. Among many chromatin disorders we will discuss Rett and immunodeficiency, centromeric instability and facial anomalies (ICF) syndromes. Both … Read more