New animal models for understandingof the role of MeCP2 and the development of approachespharmacological

Reference: PROJECT1 Abstract: Objective: confirmed the reversibility of the syndrome Rett, a possible therapeutic approach could result by pharmacological modulation of molecular pathways regulated by MeCP2. In this project we will remove MeCP2 from cerebral cortex and hippocampus, areas in which they reside most of the cognitive and affective, to determine the “MeCP2 target genes” … Read more

Cell lines and DNA bank of Rett syndrome and other X-linked mental retardation

Reference: GTF05005 Abstract: Mental retardation (MR) is the most frequent cause of serious handicap in humans and an important health-care problem throughout the world. It is estimated to occur in about 1-3% of the general population. It is calculated that X-linked mental retardation (XLMR) may account for about 20ヨ25% of mentally retarded males. The number … Read more

Integrated outpatient rehabilitation and improving the quality of life in Rett syndrome

Reference: 6 Abstract: Continues in Milan, Istituto Don Calabria, the “integrated approach to rehabilitation and improvement of the quality of life in Rett Syndrome” started in March 2011 through the call for projects to assist the Mariani Foundation and in collaboration with AIRETT. The project envisages an integrated rehabilitation assessment (motor aspects, interpersonal, communication and … Read more

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