MECP2 PHOSPHORYLATION AND RELATED KINASES IN RETT SYNDROME

Reference: RF-IRE-2008-1231829 Abstract: n.a PROJECT DETAILS  beginning: 2010. end: 2013. Country of research: Italy Counry of funding source: Italy Funding organization: Ministry of Health, Programma per la Ricerca Sanitaria 2008: attivit? di ricerca sulle Malattie Rare Financing: NATIONAL FUNDINGS – 230 769 € hyperlink

Induced pluripotent stem cells as in vitro models for the study of Rett syndrome pathogenesis and identification of therapeutic targets

Reference: RF-TOS-2008-1225570 Abstract: n.a PROJECT DETAILS  beginning: 2010. end: 2013. Country of research: Italy Counry of funding source: Italy Funding organization: Ministry of Health, Programma per la Ricerca Sanitaria 2008: attivit? di ricerca sulle Malattie Rare Financing: NATIONAL FUNDINGS – 164 120 € hyperlink

Increased levels of 4HNE-protein plasma adducts in Rett syndrome.

Reference: Abstract: Rett syndrome (RTT) is a neurological disorder and a leading cause of mental retardation in females. It is caused by mutations in methyl-CpG-binding protein 2 (MeCP2) gene and more rarely in cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1) genes. Increased oxidative stress (OS) has been documented in MeCP2-RTT patients. Here, … Read more

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