Determination of the kinetic behaviour of methyl-CpG-binding proteins MeCP2 and MBD1 in living cells by applying fluorescence recovery after photobleaching (FRAP)

Reference: Abstract: PROJECT DETAILS  beginning: 2004. end: 2006. Country of research: Germany Counry of funding source: Germany Funding organization: GermanᅠResearch Foundation Financing: NATIONAL FUNDINGS – 0 € hyperlink

Analysis of transcriptional repression and DNA binding of MeCP2 and its significance for Rett Syndrome (B 2)

Reference: B2 – Subproject to SFB 545: Molecular mechanisms of genetic diseases Abstract: PROJECT DETAILS  beginning: 1997. end: 2003. Country of research: Germany Counry of funding source: Germany Funding organization: GermanᅠResearch Foundation Financing: NATIONAL FUNDINGS – 0 € hyperlink

Molecular signals for synaptic pruning by microglia

Reference: 327409 Abstract: While emerging body of evidence implicates microglia in synaptic pruning and indicates the role of complement system in mediating phagocytosis of synaptic elements by surrounding microglia, no neuronal signals that label synapses according to their activity and maturity have been identified yet. Here we propose to develop an organotypic hippocampal slice culture … Read more

GEUVADIS Genetic European Variation in Health and Disease, A European Medical Sequencing Consortium

Reference: 261123 Abstract: We are committed to gaining insights into the human genome and its role in health and medicine by sharing data, experience and expertise in high-throughput sequencing. The purpose of this website is to keep you up to date with the project, and to help you find accessible information about genomics and personalised … Read more

Genetic and Epigenetic Networks in Cognitive Dysfunction

Reference: 241995 Abstract: Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology … Read more

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