Analysis of transcriptional repression and DNA binding of MeCP2 and its significance for Rett Syndrome (B 2)

Reference: B2 – Subproject to SFB 545: Molecular mechanisms of genetic diseases Abstract: PROJECT DETAILS  beginning: 1997. end: 2003. Country of research: Germany Counry of funding source: Germany Funding organization: GermanᅠResearch Foundation Financing: NATIONAL FUNDINGS – 0 € hyperlink

Determination of the kinetic behaviour of methyl-CpG-binding proteins MeCP2 and MBD1 in living cells by applying fluorescence recovery after photobleaching (FRAP)

Reference: Abstract: PROJECT DETAILS  beginning: 2004. end: 2006. Country of research: Germany Counry of funding source: Germany Funding organization: GermanᅠResearch Foundation Financing: NATIONAL FUNDINGS – 0 € hyperlink

Epigenetic Plasticity of the Genome

Reference: 503433 Abstract: In this ‘post-genomic’ era, advances in epigenetic research represent a new frontier that is predicted to yield novel insights for gene regulation, cell differentiation, stem cell plasticity, organismal development, human diseases, cancer, infertility and aging. A central emerging concept proposes that there is an ‘epigenetic code’, which considerably extends the information potential … Read more

When Neurons Touch-Elucidating the Role of Neuroligins in the Formation, Development, Maturation, and Maintenance of Synapses

Reference: 274972 Abstract: The proper coupling between presynaptic and postsynaptic neurons is essential for synaptic signalling. Synapse formation, maturation, and maintenance are controlled by cell adhesion systems that recruit and organise the synaptic protein machinery. One such system comprises presynaptic neurexins and postsynaptic neuroligins. Of the five known neuroligins, neuroligin 1 is specific for excitatory … Read more

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