Reference: 40712 Abstract: To obtain the diversity of cells present in the human brain, different signalling molecules are repeatedly used to regionalise the central nervous system (CNS). In this work we used the zebrafish as an organism model to find which signal pathways are involved in the anterior brain formation and when do they act. … Read more
Reference: 327409 Abstract: While emerging body of evidence implicates microglia in synaptic pruning and indicates the role of complement system in mediating phagocytosis of synaptic elements by surrounding microglia, no neuronal signals that label synapses according to their activity and maturity have been identified yet. Here we propose to develop an organotypic hippocampal slice culture … Read more
Reference: ORPHA258004 Abstract: Rett syndrome (RS) is a neurological disorder primarily affecting girls, with an incidence of about 1/10,000 female births. It is a genetic disease, the second cause of severe mental retardation in women and a leading cause of postnatal neurodevelopmental regression. Rett syndrome is a model for autism-spectrum disorders and it is classified … Read more
Reference: 274972 Abstract: The proper coupling between presynaptic and postsynaptic neurons is essential for synaptic signalling. Synapse formation, maturation, and maintenance are controlled by cell adhesion systems that recruit and organise the synaptic protein machinery. One such system comprises presynaptic neurexins and postsynaptic neuroligins. Of the five known neuroligins, neuroligin 1 is specific for excitatory … Read more
Reference: 261123 Abstract: We are committed to gaining insights into the human genome and its role in health and medicine by sharing data, experience and expertise in high-throughput sequencing. The purpose of this website is to keep you up to date with the project, and to help you find accessible information about genomics and personalised … Read more
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