2015.

Characterization of neuronal activity-dependent gene transcription regulation in human iPSC-derived neurons

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Reference: MJD350 Abstract: Cellular and molecular studies of the human brain are mostly performed on postmortem tissue or animal models. Recently however, induced pluripotent cell (iPSCs) technology has become a valuable tool that enables studies on live human iPSC-derived neurons, thus providing an alternative approach with clear advantages over animal models or postmortem tissue for … Read more

Molecular signals for synaptic pruning by microglia

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Reference: 327409 Abstract: While emerging body of evidence implicates microglia in synaptic pruning and indicates the role of complement system in mediating phagocytosis of synaptic elements by surrounding microglia, no neuronal signals that label synapses according to their activity and maturity have been identified yet. Here we propose to develop an organotypic hippocampal slice culture … Read more

NEONATAL HI INJURY – Modulation of Triggering receptor expressed in myeloid cells 2 by gene transfer as novel neuroprotective estrategy for neonatal hypoxic ischemic brain injury using behavioural outcome as readout

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Reference: 253110 Abstract: Insults during the perinatal stage of brain development lead to major causes of neurological disability throughout life, ranging from motor deficits, cognitive limitations, learning difficulties and even severe disabilities, such as cerebral palsy. In term newborn infants, hypoxic-ischemic (HI) brain injury is the most common cause of encephalopathy and seizures. Despite major … Read more

Genetic and Epigenetic Networks in Cognitive Dysfunction

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Reference: 241995 Abstract: Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology … Read more

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