Preclinical evaluation of a protein produced by Escherichia coli as a novel therapeutic approach for Rett Syndrome

Reference: 2 Abstract: In a recent study, we have reported that the administration of a toxin derived from bacteria, for brevity called CNF1, improved in a clear manner some of the behavioral alterations observed in transgenic mice, a model for Rett syndrome. CNF1 The result is also able to counteract some morphological abnormalities in the … Read more

stiftungslehrstuhle neurowissenschaften

Reference: Prof. Dr. Oliver Brustle Abstract: PROJECT DETAILS  beginning: 2012. end: 2013. Country of research: Germany Counry of funding source: Germany Funding organization: Hertie Foundation Financing: PRIVATE FUNDERS – 246 000 € hyperlink

Mitochondrial dysfunction and cytosolic redox imbalance in Rett syndrome

Reference: Michael Müller Abstract: Rett patients and mouse models of Rett syndrome, i.e. mice carrying mutations in the gene coding for the transcriptional regulator MeCP2, suffer from highly irregular breathing with temporary arrest of breathing, which gives rise to repeated episodes of reduced systemic oxygen supply (hypoxia). Yet, instead of desensitization or neuronal adaptation to … Read more

The Voice of Rett

Reference: 3750 Marschik Peter Abstract: n.a PROJECT DETAILS  beginning: 2013. end: 2015. Country of research: Austria Counry of funding source: Austria Funding organization: Franz-Lanyar-Stiftung, Graz, Austria Financing: PRIVATE FUNDERS – 13 604 € hyperlink

Transgenic approaches to understanding astrocyte heterogeneity

Reference: BB/L003236/1 Abstract: The cells in our brain are generally divided into two major categories based on their function – neurons (commonly known as nerve cells) and glial cells. Neurons are very important to our body because they process and transmit information to control our actions in daily life, while glial cells are seen as … Read more

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