2011.

Regulation of the neurotrophic factor BDNF gene expression in health and nervous system diseases

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Reference: ETF8844 Abstract: Neurotrophin brain-derived neurotrophic factor (BDNF) is a growth factor that has important roles in the development and functioning of nervous system by promoting the survival, differentiation and synaptic plasticity of specific neuronal populations. BDNF has received particular interest for its dysregulation in nervous system disorders. Decreases of BDNF and its receptor TrkB … Read more

Joint project: European Rett Syndrome Network (EURORETT).ﾠShare TU Darmstadt.ﾠ

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Reference: 01GM0811 TIB Abstract: Although the biochemical function of the proteins involved in this disorder is known, the pathophysiological mechanisms are still mysterious, stressing the need for synergy and multidisciplinarity. Because Rett syndrome could be reversible, it is a priority to combine all possible approaches understand disease mechanisms. This could allow the rapid translation of … Read more

Modulators of bio-aminergic pathways for the treatment of Rett syndrome

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Reference: ANRn.a.8-BIOTn.a.020 Abstract: Rett syndrome (RS) is a severe neurological disorder caused by a mutation in the MECP2 gene transcriptional repressor. SR girls develop normally until 6-18 months later, they suffer neurological symptoms and severe respiratory ?irregularities. So far no treatment is available. Previously, using a mouse model of SR, we have shown that disruption … Read more

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