Mitochondrial dysfunction and cytosolic redox imbalance in Rett syndrome

Reference: Michael Müller Abstract: Rett patients and mouse models of Rett syndrome, i.e. mice carrying mutations in the gene coding for the transcriptional regulator MeCP2, suffer from highly irregular breathing with temporary arrest of breathing, which gives rise to repeated episodes of reduced systemic oxygen supply (hypoxia). Yet, instead of desensitization or neuronal adaptation to … Read more

Early signs of rett syndrome

Reference: Marschik Peter Abstract: n.a PROJECT DETAILS  beginning: 2009. end: 2011. Country of research: Austria Counry of funding source: Austria Funding organization: Theodor-K�rner-Fonds AK Wien – Theodor K�rner Fonds, Prinz Eugen Stra�e 20-22, 1040 Wien, Austria Financing: PRIVATE FUNDERS – 0 € hyperlink

Regulation of the neurotrophic factor BDNF gene expression in health and nervous system diseases

Reference: ETF8844 Abstract: Neurotrophin brain-derived neurotrophic factor (BDNF) is a growth factor that has important roles in the development and functioning of nervous system by promoting the survival, differentiation and synaptic plasticity of specific neuronal populations. BDNF has received particular interest for its dysregulation in nervous system disorders. Decreases of BDNF and its receptor TrkB … Read more

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