2009.

Early signs of rett syndrome

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Reference: Marschik Peter Abstract: n.a PROJECT DETAILS  beginning: 2009. end: 2011. Country of research: Austria Counry of funding source: Austria Funding organization: Theodor-K�rner-Fonds AK Wien – Theodor K�rner Fonds, Prinz Eugen Stra�e 20-22, 1040 Wien, Austria Financing: PRIVATE FUNDERS – 0 € hyperlink

Neuroscience, neurology and psychiatry (NEURO) 2006 project�ANR-MeCP2synapse -Study of synaptic and neuronal physiological alterations in the MeCP2 gene deficient animals models of Rett syndrome

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Reference: ANRn.a.6-NEURn.a.003 Abstract: PROJECT SUMMARY – Scientific Background and Objectives�Mutations in the gene encoding the protein MeCP2, a transcriptional regulator binding methylated DNA, are causing neurological disorders – including Rett syndrome (RTT) – characterized by an apparently brain development normal.�The mice with truncated versions of MeCP2 show similar neurological deficits in patients RTT.�Deficits in dendritic … Read more

ROLE OF EXCITATION AND INHIBITION IN RETT SYNDROME

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Reference: 5F31MH078678n.a.2 Abstract: MeCP2 is a transcriptional repressor critical for normal neurological function. Rett syndrome (RTT) is a progressive neurodevelopmental disease caused by predominantly loss of function mutations in the X-linked gene encoding the transcriptional repressor, methyl-CpG-binding protein 2 (MECP2) genes. Classic RTT patients exhibit a spectrum of neurological phenotypes that include tremors, ataxia, seizures, … Read more

Replication and translation of epigenetic information

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Reference: SPP 1129 Abstract: Methyl-cytosine binding proteins (MeCPs) play a central role in the mediation of epigenetic effects. They bind to methylated sites in the DNA, recruit histone deacetylases (HDACs9 which may then cause chromatin condensation and transcriptional silencing. We have previously studied the dynamics of DNA replication in living mammalian cells using fluorescence labeling … Read more

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