Reference:
B03 – Subproject to SFB 992: Medical Epigenetics (MEDEP) From basic mechanisms to clinical applications
Abstract:
The methyl-CpG-binding protein 2 (MeCP2) detects symmetrically methylated cytosine-guanine sequences (CpG) in the genomic DNA and modulate gene expression by recruiting coactivator and corepressor-proteins.ﾠWe found that MeCP2 is significantly downregulated in hypertrophic and failing heart.ﾠThe functional significance of MeCP2 and DNA methylation in the heart is unknown.ﾠIn particular of DNA methylation and its recognition by MeCP2 – – Therefore, in this project the epigenetic mechanisms will be identified that contribute to the remodeling in the heart in the development and regression of cardiac hypertrophy and failure.
PROJECT DETAILS
beginning: 2012.
end: n.a
Country of research: Germany
Counry of funding source: Germany
Funding organization: GermanﾠResearch Foundation
Financing: NATIONAL FUNDINGS – 0 €