Reference: ORPHA267379 Abstract: PROJECT DETAILS beginning: n.a end: n.a Country of research: Germany Counry of funding source: Germany Funding organization: German Research Foundation Financing: NATIONAL FUNDINGS – 0 € hyperlink
Reference: ETF8844 Abstract: Neurotrophin brain-derived neurotrophic factor (BDNF) is a growth factor that has important roles in the development and functioning of nervous system by promoting the survival, differentiation and synaptic plasticity of specific neuronal populations. BDNF has received particular interest for its dysregulation in nervous system disorders. Decreases of BDNF and its receptor TrkB … Read more
Reference: MJD350 Abstract: Cellular and molecular studies of the human brain are mostly performed on postmortem tissue or animal models. Recently however, induced pluripotent cell (iPSCs) technology has become a valuable tool that enables studies on live human iPSC-derived neurons, thus providing an alternative approach with clear advantages over animal models or postmortem tissue for … Read more
Reference: 248284 Abstract: Rett Syndrome (RTT) is an X-linked neuro-developmental disorder and the leading known genetic cause of autism in girls. RTT is characterized by normal early development followed by cognitive, motor and language regression. Mutations in the X-linked MECP2 (methyl-CpG binding protein 2) gene account for at least 80% of RTT cases. In mouse … Read more
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