in vitro functional study

NEONATAL HI INJURY – Modulation of Triggering receptor expressed in myeloid cells 2 by gene transfer as novel neuroprotective estrategy for neonatal hypoxic ischemic brain injury using behavioural outcome as readout

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Reference: 253110 Abstract: Insults during the perinatal stage of brain development lead to major causes of neurological disability throughout life, ranging from motor deficits, cognitive limitations, learning difficulties and even severe disabilities, such as cerebral palsy. In term newborn infants, hypoxic-ischemic (HI) brain injury is the most common cause of encephalopathy and seizures. Despite major … Read more

Molecular signals for synaptic pruning by microglia

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Reference: 327409 Abstract: While emerging body of evidence implicates microglia in synaptic pruning and indicates the role of complement system in mediating phagocytosis of synaptic elements by surrounding microglia, no neuronal signals that label synapses according to their activity and maturity have been identified yet. Here we propose to develop an organotypic hippocampal slice culture … Read more

WDVPT (Role of the Wnt/b-catenin pathway in the dorso-ventral organisation of the telencephalon.)

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Reference: 40712 Abstract: To obtain the diversity of cells present in the human brain, different signalling molecules are repeatedly used to regionalise the central nervous system (CNS). In this work we used the zebrafish as an organism model to find which signal pathways are involved in the anterior brain formation and when do they act. … Read more

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