Reference: Abstract: The focus of this project are epigenetic mechanisms that underlie the remodeling in the heart in the emergence of hypertrophy and failure and recovery after mechanical unloading.ﾠIn the foreground is the methyl-DNA-binding protein 2 (MeCP2), which specifically recognizes methylated DNA sequences, and thus can modulate gene expression.ﾠIn the continuation phase of this project, … Read more
Reference: Abstract: PROJECT DETAILS beginning: 2004. end: 2006. Country of research: Germany Counry of funding source: Germany Funding organization: GermanﾠResearch Foundation Financing: NATIONAL FUNDINGS – 0 € hyperlink
Reference: Abstract: Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have recently been reported in patients with severe neurodevelopmental disorder characterized by early-onset seizures, infantile spasms, severe psychomotor impairment and very recently, in patients with Rett syndrome (RTT)-like phenotype. Although the involvement of CDKL5 in specific biological pathways and its neurodevelopmental role have not … Read more
Reference: 274972 Abstract: The proper coupling between presynaptic and postsynaptic neurons is essential for synaptic signalling. Synapse formation, maturation, and maintenance are controlled by cell adhesion systems that recruit and organise the synaptic protein machinery. One such system comprises presynaptic neurexins and postsynaptic neuroligins. Of the five known neuroligins, neuroligin 1 is specific for excitatory … Read more
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