animal model creation/study

Preclinical evaluation of a protein produced by Escherichia coli as a novel therapeutic approach for Rett Syndrome

by

Reference: 2 Abstract: In a recent study, we have reported that the administration of a toxin derived from bacteria, for brevity called CNF1, improved in a clear manner some of the behavioral alterations observed in transgenic mice, a model for Rett syndrome. CNF1 The result is also able to counteract some morphological abnormalities in the … Read more

A Mouse Model of CDKL5 Rett syndrome

by

Reference: Amendola, Elena Abstract: Rett syndrome is a neurodevelopmental disorder most commonly caused by mutations in the MECP2 gene. However, some persons with Rett do not carry mutations in MECP2 and recently mutations in the cyclin dependent kinase-like 5 (CDKL5) gene have been found in persons having a Rett-like disorder that includes seizures during the … Read more

Mitochondrial dysfunction and cytosolic redox imbalance in Rett syndrome

by

Reference: Michael Müller Abstract: Rett patients and mouse models of Rett syndrome, i.e. mice carrying mutations in the gene coding for the transcriptional regulator MeCP2, suffer from highly irregular breathing with temporary arrest of breathing, which gives rise to repeated episodes of reduced systemic oxygen supply (hypoxia). Yet, instead of desensitization or neuronal adaptation to … Read more

Study of synaptic and neuronal physiological alterations in the MeCP2 gene deficient animals models of Rett syndrome

by

Reference: ANRn.a.6-NEURn.a.003 Abstract: PROJECT SUMMARY – Scientific Background and Objectives Mutations in the gene encoding the protein MeCP2, a transcriptional regulator binding methylated DNA, are causing neurological disorders – including Rett syndrome (RTT) – characterized by an apparently brain development normal. The mice with truncated versions of MeCP2 show similar neurological deficits in patients RTT. … Read more

Transgenic approaches to understanding astrocyte heterogeneity

by

Reference: BB/L003236/1 Abstract: The cells in our brain are generally divided into two major categories based on their function – neurons (commonly known as nerve cells) and glial cells. Neurons are very important to our body because they process and transmit information to control our actions in daily life, while glial cells are seen as … Read more

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close