Editorial Team

Pharmacological treatment of respiratory disorders in a mouse model of Rett syndrome

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Reference: Paton, Julian Abstract: Breathing abnormalities consisting of rapid deep respiration followed by cessation of breathing and an irregular interval between breaths are a common and distressing feature of Rett syndrome (RTT). Using a mouse model we have shown that injections of a compound that boosts the brain concentration of the inhibitory neurotransmitter ? amino-butyric … Read more

Understanding and rescuing respiratory arrhythmias in a mouse model of Rett Syndrome

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Reference: Ana Abdala Sheikh Abstract: Breathing is the most important process controlled by the brain; it is a rhythm that happens non-stop from birth until death. It constantly changes to allow for other behaviors such as speech, singing, exercising, eating, drinking, coughing. Frequent periods of breath holding are a very common feature of Rett syndrome. … Read more

The contribution of histone deacetylases to the emergence of rett syndrome investigated by in vitro and in vivo mouse model systems

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Reference: Lagger, Sabine Abstract: n.a PROJECT DETAILS  beginning: 2011. end: 2013. Country of research: United Kingdom Counry of funding source: Germany Funding organization: EMBO Long Term fellowship Financing: PRIVATE FUNDERS – 34 079 € hyperlink

A ChIP-on-chip system for dissecting genetic pathways involved in developmental language disorders

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Reference: Fisher Simon Abstract: The Fisher lab has previously reported that mutations of a gene, called FOXP2, cause a severe developmental communication disorder. FOXP2 abnormalities lead to problems with articulating speech, accompanied by impairment in many aspects of language ability. The protein made by FOXP2 controls the behavior of cells by binding to DNA and … Read more

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