Induced pluripotent stem cells as in vitro models for the study of Rett syndrome pathogenesis and identification of therapeutic targets

Reference: RF-TOS-2008-1225570 Abstract: n.a PROJECT DETAILS  beginning: 2010. end: 2013. Country of research: Italy Counry of funding source: Italy Funding organization: Ministry of Health, Programma per la Ricerca Sanitaria 2008: attivit? di ricerca sulle Malattie Rare Financing: NATIONAL FUNDINGS – 164 120 € hyperlink

MECP2 PHOSPHORYLATION AND RELATED KINASES IN RETT SYNDROME

Reference: RF-IRE-2008-1231829 Abstract: n.a PROJECT DETAILS  beginning: 2010. end: 2013. Country of research: Italy Counry of funding source: Italy Funding organization: Ministry of Health, Programma per la Ricerca Sanitaria 2008: attivit? di ricerca sulle Malattie Rare Financing: NATIONAL FUNDINGS – 230 769 € hyperlink

Modeling of pathogenic breathing pattern dysregulation in cardiopulmonary disease

Reference: 5R33HL087347 Abstract: Ventilatory arrhythmia plays a pathogenic role in many common respiratory disorders ranging from sleep apnea, and acute lung injury to ventilatory support in the setting of chronic lung disease. Brainstem neural circuits that control cardiopulmonary functions generate oscillatory patterns that drive respiratory as well as sympathetic motor activities. These patterns exhibit highly … Read more

Modulators of bio-aminergic pathways for the treatment of Rett syndrome

Reference: ANRn.a.8-BIOTn.a.020 Abstract: Rett syndrome (RS) is a severe neurological disorder caused by a mutation in the MECP2 gene transcriptional repressor. SR girls develop normally until 6-18 months later, they suffer neurological symptoms and severe respiratory ?irregularities. So far no treatment is available. Previously, using a mouse model of SR, we have shown that disruption … Read more

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