Editorial Team

Rett Syndrome and Hanefeld variant:analysis of the molecular pathways common to both diseases

by

Reference: Project5 Abstract: Rett syndrome and its variant “of Hanefeld” are caused by mutations that affect two different genes, respectively MeCP2 and CDKL5. The aim of this project is the systematic analysis of the gene expression profile of neurons lacking MeCP2 or CDKL5. From the comparison of the obtained data we can determine which pathways … Read more

Role of MeCP2 in the proliferationand in the differentiation of the cerebral cortex

by

Reference: Project4 Abstract: Objective: the production of MeCP2 starts very early during development of the central nervous system; although at 14 days after conception the cerebral cortex of mice expressing high levels of MeCP2, the role of MeCP2 during these phases has so far been overlooked. it is our opinion that MeCP2 and in particular … Read more

Creating an experimental modelreproducing a pathogenic mutation of MeCP2

by

Reference: Project3 Abstract: Objective: the majority of animal models of the syndrome Rett available today represent only part of what that actually happens in patients, because most patients are not deprived of the entire gene, but only a small portion of it, or even have change only one amino acid. This project has set itself … Read more

Determination of the role of MeCP2in adult life

by

Reference: PROJECT2 Abstract: The objective of this project is to determine whether the role of MeCP2 runs out during the early stages of development organism, once induced neuronal maturation, or whether it may also be important in advanced stages of life, possibly exerting a maintenance of different biological activities. The transgenic model we have created … Read more

Cell lines and DNA bank of Rett syndrome and other X-linked mental retardation

by

Reference: GTF05005 Abstract: Mental retardation (MR) is the most frequent cause of serious handicap in humans and an important health-care problem throughout the world. It is estimated to occur in about 1-3% of the general population. It is calculated that X-linked mental retardation (XLMR) may account for about 20οΎ–25% of mentally retarded males. The number … Read more

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close